Renal Proliferative and Phenotypic Changes in Rats With Two-Kidney, One-Clip Goldblatt Hypertension

Dietary potassium and the development of hypertension in two-kidney, one clip Goldblatt hypertensive rats.

Importance of the renal nerves in established two-kidney, one clip Goldblatt hypertension.

Increased sympathetic nervous system activity has been demonstrated in established twokidney, one clip hypertension in the rat. To determine the importance of the renal nerves in this model of hypertension, renal denervation of the clipped kidney (n = IS), renal denotation of the nondlpped kidney (n = 14), sham operation (n = 20), or undlpping (n = 12) was carried out 6 weeks after the onset of...

Increased angiotensin-converting enzyme activity of aorta in two-kidney, one-clip Goldblatt hypertension in rats.

There is increasing evidence that conversion of angiotensin I into angiotensin I1 can occur in the renal vasculature of humans [l l , and in the vascular beds of the hind limb of the dog 121. In previous experiments the specific angiotensionconverting enzyme in rat aorta [31 has been demonstrated. More recently, Mizuno et al. [41 have studied the subcellular localization of the enzyme activity ...

Effects of saralasin infusion on bilateral renal function in two-kidney, one-clip Goldblatt hypertensive rats.

1. Previous studies have shown that administration of converting enzyme inhibitor (CEI, SQ 20 881) to two-kidney, one-clip Goldblatt hypertensive (GH) rats clipped for 3-4 weeks resulted in marked increases in glomerular filtration rate (GFR), water and sodium excretion by the non-clipped kidneys. The clipped kidneys exhibited reduced function that was due, in part, to the reductions in arteria...

Renal expression of aminopeptidase A in rats with two-kidney, one-clip hypertension.

BACKGROUND Angiotensin II (ANG II) is a major factor involved in the progression of chronic renal disease. Although the generation of this vasoactive peptide has been investigated in great detail, only a few studies have hitherto addressed the metabolism of ANG II into fragments such as angiotensin III and IV (ANG III, IV) which may exert physiological effects independent of ANG II. Aminopeptid...